PhD student Katrin Mangold has developed a technique to study gene function in embryonic development more rapidly than is possible with conditional knockouts. NEPTUNE: neural plate targeting by in utero nanoinjection. Here it is, on bioRxiv. 95% of cells in brain are transduced, conditional expression can be acheived with mini-Promotors, and we obtained a really interesting phenotype knocking down Sptbn2… Importantly, this can also reduce the numbers of mice used in science dramatically.
Andersson Lab is awarded the Swedish Foundation’s Starting Grant – an equivalent to the European Research Council Starting Grant. This collaboration between the Erling-Persson Family Foundation, the Kempe Foundations, the Foundation Olle Engkvist Byggmästare, Ragnar Söderberg Foundation and Riksbankens Jubileumsfond welcomes applications from researchers ranked A in the ERC Starting Grant, and recommended for funding, but for whom there was not sufficient funds in the ERC budget.
Read the press release here, and an interview here. We are deeply grateful to all the participating foundations for their initiative, in particular the Ragnar Söderberg Foundation that funded our Swedish Foundation Starting Grant in this round.
Organs are 3D & our analysis of pathology should be too. So we developed DUCT to visualize and quantify the 3D architecture of the murine liver vascular and biliary systems. – leading to new discoveries in Alagille syndrome. Now in bioRxiv!
Emma was elected the Scientific Committee of the EASL Governing Board. EASL brings together over 4,000 members, organizes a yearly meeting for over 9,000 attendees and aims “spread knowledge and expertise in best practices and the latest scientific breakthroughs in hepatology”, through education, conferences and more.
This year, Jan Masek, post doc, presented his ongoing and planned work as part of the Sheila Sherlock post doctoral fellowship he received.
Emma chaired sessions on “Automimmune and cholestatic liver disease”, and “Clinical developments in rare liver disease.”
Emma also gave a talk on the “Challenges women face in academia”, which you can view here.
All in all, a very exciting meeting, presenting new developments in basic, clinical and translational research, and opening the door to an exciting future three years as Governing Board member.
Special Issue of Developmental Biology, “Signaling Pathways in Development” is out now, Guest Edited By Emma R Andersson and Jeff Bush.
Our book chapter on Future Therapeutic Approaches for Alagille Syndrome is published. This book, with chapters from leaders in the field of Alagille syndrome, spanning liver pathology to bone defects, was edited by Binita Kamath and Kathy Loomes.
Welcome to our new postdoc, Emine Ezel Cilek!
Emma attends the exciting Gordon Research Conference on Notch Signaling in Development, Regeneration and Disease as discussion leader. Lots of great talks, wonderful colleagues and a flash flood to boot.
Emma has been working as Guest Editor on a special issue in Developmental Biology on the Blueprint for life… The focus is signaling pathways in development, spanning different model organisms and concepts from ligand dispersal to lateral inhibition and autophagy. The Editorial Introduction, written with Jeffrey Bush from UCSF is published – looking forward to the full issue being ready soon!
Emma presents some of our work on Notch in liver cancer at the The 8th International Conference on Notch Targeting in Cancer.
Congratulations David Kosek on a successful registration seminar and welcome as our newest PhD student!
Today Jan Masek, post doc in our lab, recieved the prestigious EASL (European Association for the Study of the Liver) Sheila Sherlock post doctoral fellowship at the International Liver Congress! Congratulations again Janek! It was a great conference, and we struck up lots of new great collaborations!
Noemi van Hul joins our lab in a Senior Scientist type of position. -Welcome Noemi!
David Kosek joins our lab as a doctoral student candidate. -Welcome David!
Congratulations Jan Masek, post doc in our lab, on being awarded the prestigious EASL (European Association for the Study of the Liver) Sheila Sherlock post doctoral fellowship! This internationally competitive post doc grant is awarded to two-three fellows in Europe each year.
Jingyan He is officially registered as a PhD student in our lab at the Department of Cell and Molecular Biology at Karolinska Institutet. Congratulations, and welcome!
Our open access Gastroenterology paper is finally out! In this paper, we describe a novel model for Alagille syndrome, which we then compare with human liver samples from patients with Alagille syndrome. By cross-referencing with the Human Protein Atlas, we identify novel markers of bile ducts and show that the apical side of bile ducts is specifically disrupted. Finally, we show that the missense mutation driving the Alagille phenotype in the mouse model is Notch receptor selective – a completely novel finding with implications for ligand-receptor specificity.
Thanks to the Swedish Research Council/Vetenskapsrådet (VR) for continuing to support our 3R research.
The Swedish Heart and Lung Foundation (Hjärt-Lungfonden) has awarded the Andersson Lab a grant to study Notch signaling and stroke, focused on Alagille syndrome. Thank you to the Foundation, and the donors, for your meaningful support.
We welcome our newest PhD student candidate, Jingyan He, co-funded by a Chinese Scholarship Council grant. Welcome to the lab, Jingyan!
Emma attended the 2017 AASLD Liver meeting in Washington DC, USA – great to see so many of my liver colleagues, and discuss new models and future areas of research.
Emma acted as examinator/opponent at the PhD defence for Katerina Strakova, at Masaryk University, Czech Republic.
Marika Sjöqvist and Emma Andersson’s review on Lateral patterning cues is accepted in Developmental Biology!
Emma gave a talk at Children’s Hospital of Philadelphia, with Kathy Loomes as host.
— Emma Andersson (@EmmaRAndersson) September 26, 2017
Congratulations Afshan Iqbal on your PhD studies registration seminar! An intercontinental challenge, with Afshan presenting to the Doctoral Admissions board at Karolinska/BioNut, and Emma joining from New Haven over Skype, at 4am. All went well, and we are delighted to welcome our most recent official lab member!
From @karolinskainst to @YaleMed: Day 1 of Visiting Assistant Professorship! Thank you @EASLedu for the Mentorship Award w/ M Strazzabosco! pic.twitter.com/fsaUlTB9nN — Emma Andersson (@EmmaRAndersson) September 5, 2017
Grateful and honored to have won the EASL Mentorship award, that supports me visiting a Mentor they matched me with, in this case Mario Strazzabosco – world leading hepatologist! Starting today, I will be networking, presenting our data all over the USA, establishing collaborations and planning grant applications, for the next month. Thank you EASL for connecting me to the liver community!