The Andersson lab aims to understand how multicellular organisms develop specialized organs systems with the correct cellular identity and architecture necessary for function, and how these systems are affected in disease and regeneration. As developmental biologists, we are interested in why and how genetic mutations lead to specific defects in embryogenesis. In order to study this in depth we develop new technologies to analyze organs, or new methods to manipulate embryogenesis. We are focused on Alagille syndrome, a congenital disorder affecting development of several organ systems including the liver and vasculature. In addition to the technologies we are developing, we use mouse models, 3D cell culture, CRISPR cell lines, single cell omics, and patient samples to address fundamental questions with relevance for human health.
Nov 6, 2020
We are recruiting! After a very odd year, I hope lots of freshly minted PhDs are looking for new challenges and would consider a post doc in Sweden, in our lab! We are looking for three curious, passionate, and driven postdocs for three different projects in the lab.
The application deadline is Nov 27th, 2020.
Postdoctoral studies in single cell resolution of liver lineage development
In this project, the major goal is to elucidate the major cell lineages in developing mouse embryos, using NEPTUNE. Experiments include virus production, viral labelling of developing embryos using in utero nano-injection, and single cell RNA sequencing with 10x Genomics or SmartSeq3. Read-outs include extensive bioinformatics analyses.
For more information and to apply: Click here
Postdoctoral studies in liver development, focused on interaction of vascular, nervous and biliary systems
In this project, the major goal is to investigate the interaction of the vascular, nervous and hepatic systems during liver development, using mouse models and a technique we developed to manipulate gene expression in the nervous system, NEPTUNE. Read-outs include histology, whole mount immunofluorescence, another technique we developed: DUCT , which we developed to resolve 3D liver structures, scRNA sequencing, and viral circuitry tracing.
For more info and to apply: Click here
Postdoctoral studies in structure-function principles of miRNA control of embryonic development
In this project, the major goal is to elucidate the structure-function relationship of miR-mRNA targeting in vivo using NEPTUNE. Experiments include in utero nano-injection, cell culture, qPCR, western blot, and single cell RNA sequencing or single cell proteomics.
For more info and to apply: Click here
Sept 30, 2020
Andersson lab is awarded a Knut and Alice Wallenberg project grant to study lineages and fate choices accross organ systems during development. This major project grant is a collaboration with Igor Adameyko, Niklas Björkström, Jonas Frisén and Ulrika Marklund. We are humbled and grateful to the KAW Foundation and the reviewers – and so excited to do this project!
May 28, 2020
PhD student Katrin Mangold has developed a technique to study gene function in embryonic development more rapidly than is possible with conditional knockouts. NEPTUNE: neural plate targeting by in utero nanoinjection. Here it is, on bioRxiv. 95% of cells in brain are transduced, conditional expression can be acheived with mini-Promotors, and we obtained a really interesting phenotype knocking down Sptbn2… Importantly, this can also reduce the numbers of mice used in science dramatically.
Jan 16, 2020
Andersson Lab is awarded the Swedish Foundation’s Starting Grant – an equivalent to the European Research Council Starting Grant. This collaboration between the Erling-Persson Family Foundation, the Kempe Foundations, the Foundation Olle Engkvist Byggmästare, Ragnar Söderberg Foundation and Riksbankens Jubileumsfond welcomes applications from researchers ranked A in the ERC Starting Grant, and recommended for funding, but for whom there was not sufficient funds in the ERC budget.
Read the press release here, and an interview here. We are deeply grateful to all the participating foundations for their initiative, in particular the Ragnar Söderberg Foundation that funded our Swedish Foundation Starting Grant in this round.
Nov 21, 2019
Organs are 3D & our analysis of pathology should be too. So we developed DUCT to visualize and quantify the 3D architecture of the murine liver vascular and biliary systems. – leading to new discoveries in Alagille syndrome. This work, led by Simona Hankeova, is now in bioRxiv!
June 14 2019
Simona Hankeova, our first PhD student, succesfully defends her PhD! With excellent opposition and discussion from Dr Rui Benedito. Congratulations Dr Hankeova!
May 28, 2019
April 10-14, 2019
Emma was elected the Scientific Committee of the EASL Governing Board. EASL brings together over 4,000 members, organizes a yearly meeting for over 9,000 attendees and aims “spread knowledge and expertise in best practices and the latest scientific breakthroughs in hepatology”, through education, conferences and more.
This year, Jan Masek, post doc, presented his ongoing and planned work as part of the Sheila Sherlock post doctoral fellowship he received.
Emma chaired sessions on “Automimmune and cholestatic liver disease”, and “Clinical developments in rare liver disease.”
Emma also gave a talk on the “Challenges women face in academia”, which you can view here, or below.
All in all, a very exciting meeting, presenting new developments in basic, clinical and translational research.
March 1st, 2019
Registration to The Notch Meeting 2019 in Athens Oct 6-10, co-organized by Emma, is open now! Please register to guarantee a spot at this vibrant meeting! Lovely poster featuring blood vessels imaged by Simona Hankeova, PhD student in the lab.
March 1, 2019
Feb 11, 2019
We welcome our new PhD student Sandra de Haan to the lab!
Our book chapter on Future Therapeutic Approaches for Alagille Syndrome is published. This book, with chapters from leaders in the field of Alagille syndrome, spanning liver pathology to bone defects, was edited by Binita Kamath and Kathy Loomes.
Welcome to our new postdoc, Emine Ezel Cilek!
Emma attends the exciting Gordon Research Conference on Notch Signaling in Development, Regeneration and Disease as discussion leader. Lots of great talks, wonderful colleagues and a flash flood to boot.
Emma has been working as Guest Editor on a special issue in Developmental Biology on the Blueprint for life… The focus is signaling pathways in development, spanning different model organisms and concepts from ligand dispersal to lateral inhibition and autophagy. The Editorial Introduction, written with Jeffrey Bush from UCSF is published – looking forward to the full issue being ready soon!
Emma presents some of our work on Notch in liver cancer at the The 8th International Conference on Notch Targeting in Cancer.
Congratulations David Kosek on a successful registration seminar and welcome as our newest PhD student!
Today Jan Masek, post doc in our lab, recieved the prestigious EASL (European Association for the Study of the Liver) Sheila Sherlock post doctoral fellowship at the International Liver Congress! Congratulations again Janek! It was a great conference, and we struck up lots of new great collaborations!
Noemi van Hul joins our lab in a Senior Scientist type of position. -Welcome Noemi!
Congratulations Jan Masek, post doc in our lab, on being awarded the prestigious EASL (European Association for the Study of the Liver) Sheila Sherlock post doctoral fellowship! This internationally competitive post doc grant is awarded to two-three fellows in Europe each year.
Jingyan He is officially registered as a PhD student in our lab at the Department of Cell and Molecular Biology at Karolinska Institutet. Congratulations, and welcome!
Our open access Gastroenterology paper is finally out! In this paper, we describe a novel model for Alagille syndrome, which we then compare with human liver samples from patients with Alagille syndrome. By cross-referencing with the Human Protein Atlas, we identify novel markers of bile ducts and show that the apical side of bile ducts is specifically disrupted. Finally, we show that the missense mutation driving the Alagille phenotype in the mouse model is Notch receptor selective – a completely novel finding with implications for ligand-receptor specificity.
Thanks to the Swedish Research Council/Vetenskapsrådet (VR) for continuing to support our 3R research.
The Swedish Heart and Lung Foundation (Hjärt-Lungfonden) has awarded the Andersson Lab a grant to study Notch signaling and stroke, focused on Alagille syndrome. Thank you to the Foundation, and the donors, for your meaningful support.
Marika Sjöqvist and Emma Andersson’s review on Lateral patterning cues is accepted in Developmental Biology!
Emma gave a talk at Children’s Hospital of Philadelphia, with Kathy Loomes as host.
Emma presents at the University of Hartford Neuroscience Symposium
Congratulations Afshan Iqbal on your PhD studies registration seminar! An intercontinental challenge, with Afshan presenting to the Doctoral Admissions board at Karolinska/BioNut, and Emma joining from New Haven over Skype, at 4am. All went well, and we are delighted to welcome our most recent official lab member!
Our review is out! Read about Congenital Notch disorders and how Notch controls embryonic development in the May issue of Development.
Emma R Andersson is awarded the EASL Daniel Alagille Award! This award is given to one person in Europe under 40 for a groundbreaking project in genetic cholestatic liver disease.
Jan Mašek (with Andersson Lab as applicant) is awarded a post doc grant from the Wenner Gren Foundation! We congratulate Janek and thank the foundation for their support!
Katja Petzold (as main PI) and Emma R Andersson are awarded a grant from Knut and Alice Wallenberg’s foundation! This generous grant will allow us to build up a team and continue our collaboration investigating the role of miR structure in vivo, using ultaround-guided nanoinjection of the nervous system. For more info see http://ki.se/en/news/four-projects-to-share-143-million-from-knut-and-alice-wallenberg-foundation, https://www.wallenberg.com/kaw/sma-molekyler-styr-hjarnans-utveckling-och-cancer
Welcome to our new Post Doc Jan Mašek!
Congratulations Bettina Semsch on your promotion to Animal Technician Specialist!
Emma receives one of the competitive Assistant Professor Funding positions from Karolinska Institutet (262 applicants, 7 awarded funding, 2.7% success rate).
The Sven and Ebba-Christina Hagberg prize in medicine 2014 is awarded to Emma Andersson, Senior researcher at the Department of Biosciences and Robert Månsson, Assistant professor at the Department of Laboratory Medicine.